BernheimV1, Main, Exploration, bibRecord, 000111

Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer

Identifieur interne : 000111 ( Main/Exploration ); précédent : 000110; suivant : 000112

Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer

Auteurs : Marius Ionut Ilie [France]

Source :

RBID : Hal:tel-00874504

Descripteurs français

mix :
- Biomarqueurs, Biopathologie, Cancer du poumon, Pathologie intégrative.

English descriptors

mix :
- Biomarkers, Biopathology, Integrative pathology, Lung cancer.

Abstract

The non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the world. Reliable and validated biomarkers could represent a possible breakthrough in the management of this tumour type, by facilitating diagnosis, refining prognosis and providing guidance towards the choice of the most appropriate therapy. In this thesis we approach the field of NSCLC biomarkers by exploring several aspects related to carcinogenesis and tumour progression. First, we have demonstrated a dual impact of two proteins activated by hypoxia, carbonic anhydrases IX and XII, on the outcome of NSCLC patients. We have demonstrated that high tissue and plasma CAIX expression may be a biomarker of poor prognosis and early relapse in NSCLC patients, whereas the CAXII tissue expression would be predictive of a favourable evolution. In addition, we have shown that dynamic reoxygenation of tumours would be at the origin of this antagonism. Furthermore, the cellular component of the tumour microenvironment has been studied and more particularly we have demonstrated that recruitment by the tumour cells of a subpopulation of neutrophils expressing a specific marker CD66b could have a positive signal during tumour progression of NSCLC. Thirdly, the blood compartment has been evaluated in relationship with the evolution of tumours and in particular we have demonstrated the major diagnostic and prognostic value of circulating tumour cells (CTCs) in patients with NSCLC. Finally, the CTC seem to represent the ideal tool for the detection of biomarkers theranostic in the NCPC. In conclusions, the works presented in this thesis explore possibilities and limitations of biomarker research in NSCLC, highlighting the importance of the quality of the samples and of the accuracy and completeness of clinical data in order to obtain reproducible results.

Url:

https://tel.archives-ouvertes.fr/tel-00874504

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000040
to stream Hal, to step Curation: 000040
to stream Hal, to step Checkpoint: 000096
to stream Main, to step Merge: 000111
to stream Main, to step Curation: 000111

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer</title>
<title xml:lang="fr">Apport de la pathologie intégrative dans l'identification de biomarqueurs dans les carcinomes pulmonaires non à petites cellules : pathologie intégrative et cancer du poumon</title>
<author><name sortKey="Ilie, Marius Ionut" sort="Ilie, Marius Ionut" uniqKey="Ilie M" first="Marius Ionut" last="Ilie">Marius Ionut Ilie</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182186" status="VALID">          <orgName>Institut de Recherche sur le Cancer et le Vieillissement</orgName>
          <orgName type="acronym">IRCAN</orgName>
          <desc>            <address>              <addrLine>Faculté de médecine, 28 avenue de Valombrose 06107 Nice Cedex 2</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-117617" type="direct"></relation>
            <relation active="#struct-523042" type="direct"></relation>
            <relation name="U1081" active="#struct-303623" type="direct"></relation>
            <relation name="UMR7284" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-117617" type="direct"><org type="institution" xml:id="struct-117617" status="VALID">          <orgName>Université Nice Sophia Antipolis</orgName>
          <orgName type="acronym">UNS</orgName>
          <desc>            <address>              <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-523042" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-523042" type="direct"><org type="regroupinstitution" xml:id="struct-523042" status="VALID">          <orgName>Université Côte d'Azur </orgName>
          <orgName type="acronym">UCA</orgName>
          <date type="start">2015-03-01</date>
          <desc>            <address>              <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="U1081" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7284" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nice</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université Nice Sophia Antipolis</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:tel-00874504</idno>
<idno type="halId">tel-00874504</idno>
<idno type="halUri">https://tel.archives-ouvertes.fr/tel-00874504</idno>
<idno type="url">https://tel.archives-ouvertes.fr/tel-00874504</idno>
<date when="2013-07-12">2013-07-12</date>
<idno type="wicri:Area/Hal/Corpus">000040</idno>
<idno type="wicri:Area/Hal/Curation">000040</idno>
<idno type="wicri:Area/Hal/Checkpoint">000096</idno>
<idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000096</idno>
<idno type="wicri:Area/Main/Merge">000111</idno>
<idno type="wicri:Area/Main/Curation">000111</idno>
<idno type="wicri:Area/Main/Exploration">000111</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer</title>
<title xml:lang="fr">Apport de la pathologie intégrative dans l'identification de biomarqueurs dans les carcinomes pulmonaires non à petites cellules : pathologie intégrative et cancer du poumon</title>
<author><name sortKey="Ilie, Marius Ionut" sort="Ilie, Marius Ionut" uniqKey="Ilie M" first="Marius Ionut" last="Ilie">Marius Ionut Ilie</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-182186" status="VALID">          <orgName>Institut de Recherche sur le Cancer et le Vieillissement</orgName>
          <orgName type="acronym">IRCAN</orgName>
          <desc>            <address>              <addrLine>Faculté de médecine, 28 avenue de Valombrose 06107 Nice Cedex 2</addrLine>
              <country key="FR"></country>
            </address>
          </desc>
          <listRelation>            <relation active="#struct-117617" type="direct"></relation>
            <relation active="#struct-523042" type="direct"></relation>
            <relation name="U1081" active="#struct-303623" type="direct"></relation>
            <relation name="UMR7284" active="#struct-441569" type="direct"></relation>
          </listRelation>
        <tutelles><tutelle active="#struct-117617" type="direct"><org type="institution" xml:id="struct-117617" status="VALID">          <orgName>Université Nice Sophia Antipolis</orgName>
          <orgName type="acronym">UNS</orgName>
          <desc>            <address>              <addrLine>Parc Valrose - BP 2135 - 06103 Nice cedex 2</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://unice.fr/</ref>
          </desc>
          <listRelation>            <relation active="#struct-523042" type="direct"></relation>
          </listRelation>
        </org>
</tutelle>
<tutelle active="#struct-523042" type="direct"><org type="regroupinstitution" xml:id="struct-523042" status="VALID">          <orgName>Université Côte d'Azur </orgName>
          <orgName type="acronym">UCA</orgName>
          <date type="start">2015-03-01</date>
          <desc>            <address>              <addrLine>Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 </addrLine>
              <country key="FR"></country>
            </address>
          </desc>
        </org>
</tutelle>
<tutelle name="U1081" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">          <idno type="IdRef">026388278</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
<tutelle name="UMR7284" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
          <idno type="ISNI">0000000122597504</idno>
          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
          <desc>            <address>              <country key="FR"></country>
            </address>
            <ref type="url">http://www.cnrs.fr/</ref>
          </desc>
        </org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Nice</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université Nice Sophia Antipolis</orgName>
</affiliation>
</author>
</analytic>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Biomarkers</term>
<term>Biopathology</term>
<term>Integrative pathology</term>
<term>Lung cancer</term>
</keywords>
<keywords scheme="mix" xml:lang="fr"><term>Biomarqueurs</term>
<term>Biopathologie</term>
<term>Cancer du poumon</term>
<term>Pathologie intégrative</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths in the world. Reliable and validated biomarkers could represent a possible breakthrough in the management of this tumour type, by facilitating diagnosis, refining prognosis and providing guidance towards the choice of the most appropriate therapy. In this thesis we approach the field of NSCLC biomarkers by exploring several aspects related to carcinogenesis and tumour progression. First, we have demonstrated a dual impact of two proteins activated by hypoxia, carbonic anhydrases IX and XII, on the outcome of NSCLC patients. We have demonstrated that high tissue and plasma CAIX expression may be a biomarker of poor prognosis and early relapse in NSCLC patients, whereas the CAXII tissue expression would be predictive of a favourable evolution. In addition, we have shown that dynamic reoxygenation of tumours would be at the origin of this antagonism. Furthermore, the cellular component of the tumour microenvironment has been studied and more particularly we have demonstrated that recruitment by the tumour cells of a subpopulation of neutrophils expressing a specific marker CD66b could have a positive signal during tumour progression of NSCLC. Thirdly, the blood compartment has been evaluated in relationship with the evolution of tumours and in particular we have demonstrated the major diagnostic and prognostic value of circulating tumour cells (CTCs) in patients with NSCLC. Finally, the CTC seem to represent the ideal tool for the detection of biomarkers theranostic in the NCPC. In conclusions, the works presented in this thesis explore possibilities and limitations of biomarker research in NSCLC, highlighting the importance of the quality of the samples and of the accuracy and completeness of clinical data in order to obtain reproducible results.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Nice</li>
</settlement>
<orgName><li>Université Nice Sophia Antipolis</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Ilie, Marius Ionut" sort="Ilie, Marius Ionut" uniqKey="Ilie M" first="Marius Ionut" last="Ilie">Marius Ionut Ilie</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Psychologie/explor/BernheimV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000111 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000111 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Psychologie
   |area=    BernheimV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Hal:tel-00874504
   |texte=   Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer
}}

This area was generated with Dilib version V0.6.33.
Data generation: Mon Mar 5 17:33:33 2018. Site generation: Thu Apr 29 15:49:51 2021

	Serveur d'exploration Hippolyte Bernheim
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Hippolyte Bernheim

Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer

Contribution of the integrative pathology to the discovery of biomarkers for non-small cell lung cancer : integrative pathology and lung cancer

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri